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Tuesday, October 13, 2020 | History

2 edition of Cell kinetics in large bowel epithelium. found in the catalog.

Cell kinetics in large bowel epithelium.

Margaret Kellett

Cell kinetics in large bowel epithelium.

by Margaret Kellett

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  • 5 Currently reading

Published by University of Manchester in Manchester .
Written in English


Edition Notes

Manchester thesis (Ph.D.), Faculty of Medicine.

ContributionsUniversity of Manchester. Faculty of Medicine.
The Physical Object
Pagination328p.
Number of Pages328
ID Numbers
Open LibraryOL16572348M

Title:MicroRNA Determines the Fate of Intestinal Epithelial Cell Differentiation and Regulates Intestinal Diseases VOLUME: 20 ISSUE: 7 Author(s):Sujuan Ding, Gang Liu, Hongmei Jiang* and Jun Fang* Affiliation:College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, College of Bioscience and Biotechnology, Hunan Agricultural University, Cited by: 2. The epithelium of the small and large intestines is in close contact with ingested materials, which are absorbed by the villi. To date, studies on exposure, absorption and bioavailability are mainly focused on the inhalation and dermal routes, and little is known about the toxicokinetic and toxicodynamic processes following oral exposure Cited by: 7.

  Biomarkers in disease and health - Volume 86 Issue S1 - F. Branca, A. B. Hanley, B Pool-Zobel, H. VerhagenCited by: The survival of most normal intestinal epithelial cells (IECs) requires cell–cell and cell–matrix adhesion, and loss of such cell adhesion induces epithelial cell death that is, in part, mediated by apoptosis (Dzierzewicz et al., ; Dufour et al., ; Fouquet et al., ). Pathologically, proinflammatory cytokines such as interferon.

of large bowel, epithelial cell prolifera- tion, Adenomas, in large bowel, epithelial cell proliferation, Adenylate cyclase, GTP-binding protein, prostanoid inhibition of parietal cells (dog), Adrenocorticotropic hormone (AGTH), and stress-induced changes in in- testinal transit (rat), Aging.   Hyperplastic polyps of the colorectum are heterogeneous lesions, a subset of which is now regarded as the precursor of colorectal cancer with DNA microsatellite instability. Some authors have distinguished this subset from classic hyperplastic polyps and have introduced the term “sessile serrated adenoma”. These lesions frequently show BRAF mutation and DNA Cited by:


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Cell kinetics in large bowel epithelium by Margaret Kellett Download PDF EPUB FB2

@article{osti_, title = {Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel}, author = {Roncucci, L and Scalmati, A and Ponz de Leon, M}, abstractNote = {It is generally accepted that adenomatous polyps represent the natural precursor of many colorectal malignancies.

Enteric epithelium possesses the fastest rate of turnover of any tissue exceeded only by a few rapidly growing neoplasms. In normal circumstances, the constant turnover of small bowel mucosa is maintained by equilibrium between cell production in the crypts and cell loss at the tips of the villi.

The effect of low dose warfarin and high dose warfarin on epithelial cell kinetics (as determined by stathmokinetic techniques), and preneoplastic morphological changes was studied during. Under steady-state kinetics these cells are responsible for all the cell production, producing daughters that enter a dividing transit lineage of between six and eight generations in the small and large bowel, respectively (see Figs.

and ). The stem cells in the small intestine divide with a cycle time of approximately 24 hours; hence. The physiology of epithelial cell loss at the villus tip was historically viewed as a simple passive process of epithelial sloughing of individual cells or clusters of cells.

50 In reality, intestinal epithelial cell shedding is a highly complex process of orchestrated events that maintains contiguity of the epithelium and gut barrier function Cited by: The large bowel consists of a rapidly proliferating and perpetually differentiating epithelium.

Unlike the small intestine, the mucosal surface of the colon has no villi. Riddell RH, Levin B () Ultrastructure of the “transitional” mucosa adjacent to large bowel carcinoma. Cancer – PubMed Google Scholar Rodning CB, Wilson ID, Erlandsen SL () Immunoglobulins within human small intestinal Paneth by: Aldewachi HS, Wright NA, Appleton DR, et al: The effect of starvation and re-feeding on cell population kinetics in the rat small bowel mucosa.

J Anat. Small and Large Bowel Polyps and Tumors INTRODUCTION This chapter discusses polyps and tumors of the small and large bowel, which are primarily mucosal or epithelial. Lymphoproliferative disorders (see Chapter 4), endocrine cell tumors (see Chapter 5), or mesenchymal tumors (see Chapter 7) may also present as mucosal polyps or tumors and have been discussed.

The Enterocyte.- I. The Striated Border.- II. The Apical Cell Coat and Cell Membrane.- III. The Cores of Microvilli and the Terminal Web.- IV. Other Enterocyte Surfaces.- V. The Enterocyte Cytoplasm.- VI.

The Precursor Cells of the Crypt and Epithelial Dynamics.- VII. Special Features of Large Bowel Enterocytes.- E. Other Cell Types of. Radiation dose, fractionation and field size. Radiation dose is a major determinant of the severity of acute and late normal tissue toxicity[], the desired optimal radiation dose is defined as the dose that maximizes the difference between “tumor” and “normal tissue” damage within the sigmoid shape dose-effect relationship curve[].With respect to the gastrointestinal Cited by: Reactive gastropathy is also characterized by differences in cytoskeletal structure and cell cycle kinetics, as compared with normal gastric mucosa and H pylori gastritis.

Such changes have been studied in terms of immunohistochemical expression of CK7, CK8, CK18, CK19, CK20, and KiSpecialty: Pathology, gastroenterology. @article{osti_, title = {Regional Differences in Stem and Transit Cell Proliferation and Apoptosis in the Terminal Ileum and Colon of Mice After 12 Gy}, author = {Gandara, Ricardo M.C.

and Mahida, Yashwant R., E-mail: @ and Potten, Christopher S}, abstractNote = {Purpose: The intestinal epithelium has a high rate of cell turnover, which is. The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis.

The kinetics of tumor development were investigated using age-at-tumor diagnosis (adenomas and CRCs) of familial adenomatous coli (FAP) patients and sporadic Author: Bruce M. Boman, Arthur Guetter, Ryan M. Boman, Olaf A.

Runquist. Inflammation (from Latin: inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the.

Introduction. Vibrio parahaemolyticus is a Gram-negative bacterium that resides in the marine environment, often in association with shellfish. It is a leading cause of gastroenteritis linked to consumption of raw or undercooked seafood throughout the world, and especially in ions caused by V.

parahaemolyticus can occur sporadically or in outbreaks, which can Cited by: Inflammatory bowel diseases (IBD) have a complex, multifactorial pathophysiology with an unmet need for effective treatment. This calls for novel strategies to improve disease outcome and quality of life for patients.

Increasing evidence suggests that autonomic nerves and neurotransmitters, as well as neuropeptides, modulate the intestinal immune system, and Cited by: 4.

2 Lipkin M et al. “Cell Proliferation Kinetics In The Gastrointestinal Tract Of Man. Cell Renewal In Colon And Rectum” J Clin Invest. June; 42(6): – 3 Godlewski MM et al “Into the Unknown–The Death Pathways in the Neonatal Gut Epithelium” Current Pediatric Reviews.

7(4) Some of these included modulation of specific enzyme systems such as urokinase, reduction in paracellular permeability or promotion of epithelial cell restitution after injury in the Caco‐2 model of colonic epithelium, stimulation of mucus production in another cell line, which in turn prevented epithelial adherence of pathogenic Cited by: REVIEW Open Access Intestinal permeability – a new target for disease prevention and therapy Stephan C Bischoff1*, Giovanni Barbara2, Wim Buurman3, Theo Ockhuizen4, Jörg-Dieter Schulzke5, Matteo Serino6, Herbert Tilg7, Alastair Watson8 and Jerry M Wells9 Abstract Data are accumulating that emphasize the important role of the intestinal barrier and intestinal Cited by:.

This expansion of the villous epithelium was due to an increase in epithelial proliferation, as demonstrated by an increased (P Cited by: 9.Generation time is the time required for a cell to complete a cycle in cell division (see figure The cell cycle) and give rise to 2 daughter ant cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G 0 (resting phase).

Initial exponential tumor growth is followed .Van den Berg et al. use a zebrafish model to observe how inflammatory cells access early-stage pre-neoplastic cells in epithelia by breaching the extracellular matrix basement membrane zone.

These breaches are opportunistic, often through pre-existing weak spots, and are rate limiting for cancer cell by: 5.